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Undergoing a cosmetic treatment typically requires an out-patient visit to a clinic for treatments that can take as little as 30 minutes or less – but for some patients, those 30 minutes can be a source of anxiety. For some patients who are seeking minimally invasive treatments, confronting the discomfort of the treatment may be difficult. When that’s the case, at Zormeier Cosmetic Surgery & Longevity Center in Noblesville, IN, Shelbyville, IN, Danville, IL, Healdsburg, CA, and Ukiah, CA, we are happy to offer our patients a self-soothing tool, Pronox, which is available upon request.

What Is Pronox?

Pronox is a self-administered combination of nitrous oxide and oxygen that is used to relieve pain, stress, and anxiety during cosmetic treatments. This is an alternative pain and anxiety reliever for local anesthesia or other mild sedatives that are administered during some cosmetic treatments; this reliever can also be used in conjunction with local anesthesia.
Because this reliever is self-administered by the patient, it puts the patient in power and in total control of their level of awareness and comfort.

How Does Pronox Work?

The formula for this reliever is an even combination of 50% nitrous oxide and 50% oxygen. You might be familiar with nitrous oxide as the gas that is given before some dental procedures, such as the pulling of a tooth or the filling of cavities. Nitrous oxide can also be used to calm nerves and soothe anxiety during other treatments, including non-invasive and minimally-invasive cosmetic procedures.
The key to how this reliever works is all in the science. Nitrous oxide itself triggers the body’s pain management system, specifically the release of neurotransmitters such as dopamine that control the perception of pain in the body. When combined with oxygen and inhaled, nitrous oxide can dull pain receptors to help blunt the feeling of stress, anxiety, and pain for as long as your body is exposed to the gas.

How Do You Use This Treatment?

This treatment is used similarly to how it might be used at a dentist’s office. The reliever is inhaled through the mouth and begins to work immediately. The difference between this particular reliever and the one used in dental settings is the fact that the patient is in charge of how much nitrous oxide they are using.


This reliever uses a special patient-controlled device that allows patients to adjust the level of nitrous oxide and oxygen they are using. The device has a disposable mouthpiece that the patient uses to inhale the nitrous oxide. The absolute levels of nitrous oxide provided by the device are monitored by a certified technician.

Initial Use

The initial use of this reliever refers to the first dose that is inhaled. The first dose is typically administered a few minutes before the cosmetic treatment starts. Both the initial doses and the follow-up doses are not continuous, which means after the initial dose, the device is temporarily pulled away until it is needed again.

When Can You Use This Treatment?

You can use this reliever treatment during virtually any cosmetic treatment that might cause any slight discomfort or anxiety. This treatment can be used in tandem with other comfort medications, such as topical numbing creams, lidocaine, and local anesthesia. Some times you may want to use this treatment include:

Injectable Treatments

Injectable treatments involve the use of a thin needle to inject units of dermal fillers or neurotoxins into the skin surface. Some dermal fillers and neurotoxins already come pre-loaded with lidocaine to manage discomfort associated with the treatment, however, this might not be adequate for some patients. This is especially true for patients who are not fond of needles.

Chemical Peels

Light chemical peels, in general, do not hurt or cause significant pain sensation in the face. However, medium-strength chemical peels may cause minor discomfort while the acid is stripping away the dead skin cells on the skin surface. Additionally, depending on the sensitivity of the patient’s skin and their sensitivity to pain, even light chemical peels can be mildly uncomfortable.

Laser Resurfacing

Laser resurfacing – and other energy-based treatments for that matter – involve the use of advanced light and energy technology that may cause minor discomfort to the skin surface. Some laser resurfacing treatments necessitate the use of cooling gels to ensure patient comfort during the treatment, and for those resurfacing treatments, this reliever may be an ideal choice.


Microneedling involves using dozens of tiny needles to create micro-injuries on the surface of the skin, which is akin to being pricked by dozens of needles at a time. Understandably, microneedling can be a treatment that is a source of anxiety and moderate discomfort, even when topical numbing creams are used. This is particularly true for microneedling treatments that are combined with radiofrequency treatments.

What Are the Benefits of Pronox?

There are many benefits to this treatment beyond the fact that the reliever is familiar to many patients. The familiarity of nitrous oxide from dental offices means that it’s very easy to trust in the safety of the reliever and its use, which is especially important for patients who experience anxiety. Other benefits of this treatment include:


This is a self-administered treatment, which means that patients can determine how much nitrous oxide is being used. This may be preferable to patients who have lower pain thresholds or greater amounts of anxiety. Self-administering pain and anxiety might be better because it allows the patient to determine the exact amount required to feel comfortable.

Is This Treatment Safe?

Yes. This treatment is just as safe as using nitrous oxide provided at dental offices, provided the patient is qualified to safely use the treatment. This reliever is not addictive and it does not sedate the patient, meaning the patient is fully aware and awake at all times during the treatment.

Fewer Side Effects

Unlike general anesthesia, nitrous oxide has very few side effects thanks in large part to how quickly the effects of the gas fade. Many people who use general anesthesia experience side effects such as grogginess, confusion, vertigo, and nausea, which is unappealing.

Pronox Gives Patients Power

Undergoing cosmetic treatments are sometimes cause for anxiety for some patients.  Pronox gives patients the power to determine their own anxiety and pain relief for the duration of virtually all cosmetic treatments. Ask about using this anxiety reliever for your next cosmetic treatment.

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Amanda Roemer
Amanda Roemer
I had lip filler done over the weekend and had a great experience. Dr. Zormeier and her assistant were wonderful.
Brooke Mullen
Brooke Mullen
Dr Zormeier and her team are amazing! They listened to my concerns and developed a plan of treatment to fit my desired results. I’m addition, Dr Zormeier personally encouraged me in my journey to better overall health for myself! I am extremely satisfied with my results and will trust my ongoing care to this team. But the best part are the compliments I get from friends and family, telling me that I look amazing!
Melissa Rivera
Melissa Rivera
The ending result made it all worthwhile. Dr Zormeier I’d highly skilled and does amazing work. She is very caring and wants pics every day the first couple weeks to ensure you are doing well. Very impressed with her work!! Eyes were done perfectly!!!
Jennifer Tobian
Jennifer Tobian
Dr. Michele gave me a lower blepharoplasty and laser resurfacing in April 2022. My undereye bags were very large, and genetic and I always looked tired before. This weekend I met up with all my long distance family and friends for Thanksgiving, and everyone wants to know my secret. They ask if I’ve lost weight or have a new sleep schedule. Nope! My results are natural, beautiful and permanent. I highly recommend Dr. Michele’s skill and her nurses warm bedside manner made me feel super comfortable the whole time.
Blaise Shuman
Blaise Shuman
Great results. Great staff. Highly recommended.
vildana R
vildana R
I have had Botox, fillers, and IPL laser. I’m 38 and was noticing that I often look tired, with under eye bags, a bit of smile lines, and slightly droopy eye brows. I noticed right away that the Botox did great with lifting up my brows. The fillers gave me some cheeks and disguised the under eye bags.. my laugh lines are much less noticeable. I still have 2 more sessions of the IPL laser but so far I’ve noticed much less redness and discoloration and look forward to the final result. I did feel like Dr. Zormier cared about making sure I was comfortable. I noticed that some of the reviews mentioned that she wasn’t sensitive to pain- that was not my experience at all. If I had any criticisms- I feel like there might be a bit more fillers than I would have liked in my cheeks.. this was my first experience getting work done so perhaps I didn’t communicate with DR. zormier as thoroughly as I should have. I didn’t know what to communicate so I pretty much let her do what she thought was best. Next time I have fillers, I will ask for about 25% less than what was injected. Also, for the fillers , Botox , and IPL laser, I spent $6000 . Very expensive . I’m hopeful that maintaining is much less than this .
Melissa Rivera
Melissa Rivera
I had a blepharoplasty done to excess skin that was bothersome and also co2 fractional laser done to face and neck. There is an amazing difference and at 4 weeks I’m feeling in awe at the difference. Dr. Zormeier did a beautiful job!
James Graham
James Graham
Great Dr and Team, laser treatment worked like a charm and I would highly recommend!
Dianne Wylie
Dianne Wylie
I am very impressed with Dr. Zormeier. She gives you her full attention and makes you feel at ease and does amazing work. I am so happy with my results. Her staff is very friendly and welcoming as well. Her work is second to none. I would highly recommend her.